INDUCE-seq® Modalities and Cell Types
INDUCE-seq® is a scalable, PCR-free platform technology for high-resolution mapping and characterization of DNA double-strand breaks. By enabling in situ break capture and next-generation sequencing (NGS), it precisely detects DNA breaks induced by any nuclease-based genome editing system, without the distortion caused by PCR amplification.
Designed to meet the critical need for accurate and rapid assessment of on- and off-target editing effects, INDUCE-seq® is the first truly unbiased, cell-based solution for genome break profiling. Its versatile design allows application across any cell type, including induced pluripotent stem cells (iPSCs), T cells, and other therapeutically relevant models, making it ideal for the screening, development, and safety assessment of novel gene and cell therapies. INDUCE-seq® delivers actionable, data-driven insights to accelerate drug discovery, preclinical validation, and clinical development.
INDUCE-seq® is Compatible with any Cell Type
INDUCE-seq® in CGT Discovery and Development
INDUCE-seq can be leveraged in multiple ways to reduce drug development timelines, saving significant costs and dramatically reducing the risk of safety failures at the clinical stage.
- Confirmation of on-target gene editing
- Identification of off-target gene editing
- Guide screening
- Nuclease development and optimization
- Gene editing strategy and efficiency optimization
- Gene therapy and gene editing IND data preparation
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