Powering the future of gene editing development
The next generation of genome-wide on- and off-target analysis in your own hands
The new standard for rapid detection of gene editing-induced breaks
Scales from
discovery to IND
Support guide screening, optimization, and downstream characterization
Works across cell
types & editors
Use one approach across diverse cell models and nuclease systems
Reproducible
standardized data
Generate decision-ready outputs you can trust across programs
Single
unified workflow
Replace fragmented assays with one consistent approach
No outsourcing.
No black-box services.
Full control of your data.
The BreakMap platform powered by INDUCE-seq® delivers fast, unbiased on- and off-target analysis entirely in-house, replacing fragmented legacy workflows with a single standardized assay.
Integrated bioinformatics converts complex genome-wide sequencing data into clear, ranked outputs, for confident decision-making.
From edited cells to genome-wide insights in a single workflow
Cell editing &
immobilization
DNA break labeling
& library prep
Sequencing
Data analysis
Reporting
Reduce program risk with confident genome-wide on- and off-target insights
Identify the best-performing guides in days
Avoid late-stage failures caused by hidden off-targets
Build robust regulatory packages with empirical data
Translate sequencing data into clear, ranked on- and off-target insights
Simplify workflows and reduce dependence on bespoke assays
Identify and characterize new editing tools
We chose BaseMap because we wanted to profile our adenine base editor directly in our cells of interest, rather than assume its activity would mirror that of nuclease-based CRISPR systems. BaseMap gives us an unbiased way to investigate both on- and off-target activity, helping us understand our ABE drug mechanism, identify potential bystander editing and nominate off-target sites for further investigation. We’ve also been very pleased with how straightforward the BaseMap kit and software are to use, and with the quality and clarity of the bioinformatics reporting
Kiran Musunuru, MD, PhD, MPH, ML, MRA
Co-Director, Penn Medicine/CHOP Orphan Disease Centre
